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Inflammatory cytokines adversely affect different components of the central nervous system (CNS) and peripheral nervous system (PNS), which may, in turn, lead to degeneration of neurons and microglial cells, increased BBB permeability, as well as prolonged levels of microglial activation, which impairs neurogenesis (36, 37)

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At the level of functional intervention and therapeutic validation, multiple animal studies provide the most direct evidence

A: Visible changes can occur after the first use, and significant results are usually seen within a few days to several weeks of continuous use